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Vitamin B12 in the form of hydroxocobalamin is a vital nutrient with diverse benefits for individual health

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Since early treatment of autoimmune diseases such as RA leads to better long-term outcomes and higher chances of drug-free remission 15 , the direct targeting of intestinal barrier function at onset of arthritis provides an opportunity to modulate the development of autoimmune diseases, i.e

Additionally, the deficiency and inhibition of HDAC3 reduces the profibrotic gene expression and decreases the number and activation of myofibroblasts, ultimately alleviating UUO-induced renal fibrosis (Wang et al., 2024b)